作者
Julian U. G. Wagner,Lukas Tombor,Pedro Felipe Malacarne,Lisa-Maria Kettenhausen,Josefine Panthel,Haris Kujundzic,Nivethitha Manickam,Katja Schmitz,Maria Cipca,Kathrin A. Stilz,Ariane Fischer,Marion Muhly-Reinholz,Wesley Abplanalp,David John,Sarajo K. Mohanta,Christian Weber,Andreas J. R. Habenicht,Giulia Buchmann,Stephan Angendohr,Ehsan Amin,Katharina Scherschel,Nikolaj Klöcker,Malte Kelm,Dominik Schüttler,Sebastian Clauß,Stefan Günther,Thomas Boettger,Thomas Braun,Christian Bär,Minh Duc Pham,Jaya Krishnan,Susanne Hille,Oliver J. Müller,Tarik Bozoglu,Christian Kupatt,Eleonora Nardini,Selma Osmanagic‐Myers,Christian Meyer,Andreas M. Zeiher,Ralf P. Brandes,Guillermo Luxán,Stefanie Dimmeler
摘要
Aging is a major risk factor for impaired cardiovascular health. Because the aging myocardium is characterized by microcirculatory dysfunction, and because nerves align with vessels, we assessed the impact of aging on the cardiac neurovascular interface. We report that aging reduces nerve density in the ventricle and dysregulates vascular-derived neuroregulatory genes. Aging down-regulates microRNA 145 (miR-145) and derepresses the neurorepulsive factor semaphorin-3A. miR-145 deletion, which increased
不配.
Singularity
坚强的广山
一一
Leonardi
Yziii
paparazzi221
eternity136
8R60d8
xiaoming
shinysparrow
HEIKU
寻道图强
pluto
iNk
好困
kento
rosalieshi
tuanheqi
务实饼干
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