Rapid identification and monitoring of cooking oil fume-based toxic volatile organic aldehydes in lung tissue for predicting exposure level and cancer risks

萃取(化学) 检出限 基质(化学分析) 化学 色谱法 气相色谱-质谱法 食用油 污染 环境化学 质谱法 生物 生物化学 生态学 生物柴油 催化作用
作者
Karthikeyan Prakasham,Swapnil Gurrani,Chia-Fang Wu,Ming‐Tsang Wu,Tusty‐Jiuan Hsieh,Chiung‐Yu Peng,Po-Chin Huang,K. Anbarasu,Pei‐Chien Tsai,Yu-Chia Lin,Bongee Tsai,Yuan-Chung Lin,Vinoth Kumar Ponnusamy
出处
期刊:Chemosphere [Elsevier BV]
卷期号:339: 139704-139704 被引量:1
标识
DOI:10.1016/j.chemosphere.2023.139704
摘要

Cooking oil fumes (COFs) comprised of a mixture of cancer-causing volatile organic aldehydes (VOAs), particularly trans, trans-2,4-decadienal (t,t-DDE), 4-hydroxy-hexenal (4-HHE), and 4-hydroxy-nonenal (4-HNE). Monitoring toxic VOAs levels in people exposed to different cooking conditions is vital to predicting the cancer risk. For this purpose, we developed a fast tissue extraction (FaTEx) technique combined with UHPLC-MS/MS to monitor three toxic VOAs in mice lung tissue samples. FaTEx pre-treatment protocol was developed by combining two syringes for extraction and clean-up process. The various procedural steps affecting the FaTEx sample pre-treatment process were optimized to enhance the target VOAs' extraction efficiency from the sample matrix. Under the optimal experimental conditions, results exhibit good correlation coefficient values > 0.99, detection limits were between 0.5-3 ng/g, quantification limits were between 1-10 ng/g, and the matrix effect was <18.1%. Furthermore, the extraction recovery values of the spiked tissue exhibited between 88.9-109.6% with <8.6% of RSD. Cooking oil fume (containing t,t-DDE) treated mice at various time durations were sacrificed to validate the developed technique, and it was found that t,t-DDE concentrations were from 14.8 to 33.8 μg/g. The obtained results were found to be a fast, reliable, and semi-automated sample pre-treatment technique with good extraction efficiency, trace level detection limit, and less matrix effect. Therefore, this method can be applied as a potential analytical method to determine the VOAs in humans exposed to long-term cooking oil fumes.
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