离子迁移光谱法
质谱法
离子迁移谱-质谱
化学
分析化学(期刊)
萃取(化学)
质谱成像
色谱法
环境电离
质谱中的样品制备
离子
电离
化学电离
电喷雾电离
有机化学
作者
Rhonda Griffiths,Klaudia I. Kocurek,Helen J. Cooper
标识
DOI:10.1016/j.cbpa.2017.11.002
摘要
Ambient surface mass spectrometry encompasses a broad range of sampling and ionization techniques. To date, only a small subset of these, based on liquid microjunction extraction, have proven suitable for intact protein analysis from thin tissue sections. Liquid extraction surface analysis shows particular promise for this application. Recently, a range of ion mobility spectrometry approaches have been coupled with ambient mass spectrometry. Improvements in signal-to-noise ratios, decreased chemical noise and separation of molecular classes have been described for the analysis of various biological substrates. Similar benefits have been described for ambient mass spectrometry imaging studies. In this review, we discuss the application of ambient mass spectrometry and ion mobility spectrometry to the analysis of intact proteins, and discuss opportunities and challenges for the field.
科研通智能强力驱动
Strongly Powered by AbleSci AI