Mechanochemistry: A sustainable chemistry path

Francesco Puccetti earned his MSc in organic chemistry and synthetic procedures at the University of Florence (Italy) in 2018, after two research stays at the University of Alicante (Spain) and RWTH Aachen University (Germany). Afterward, he moved back to Aachen for his doctoral studies, focusing on mechanosynthetic protocols and reaction monitoring, under the supervision of Prof. Dr. Carsten Bolm. He further expanded his experience in this field by spending time in research groups at the Ruđer Bošković Institute (Croatia) and Hokkaido University (Japan). He graduated in January 2023. Francesco Puccetti earned his MSc in organic chemistry and synthetic procedures at the University of Florence (Italy) in 2018, after two research stays at the University of Alicante (Spain) and RWTH Aachen University (Germany). Afterward, he moved back to Aachen for his doctoral studies, focusing on mechanosynthetic protocols and reaction monitoring, under the supervision of Prof. Dr. Carsten Bolm. He further expanded his experience in this field by spending time in research groups at the Ruđer Bošković Institute (Croatia) and Hokkaido University (Japan). He graduated in January 2023. NMR in operando monitoring of mechanochemically accelerated sublimationsPuccetti et al.ChemMarch 24, 2023In BriefMethods for the monitoring of mechanochemical transformations are of fundamental importance for the understanding of property variations of the milled species. Here, the combination of mechanical grinding and NMR spectroscopy is utilized to accelerate and monitor the phenomena of self-disproportionation of enantiomers via sublimation of α-(trifluoromethyl)lactic acid. The concept of dependence of physicochemical properties on the interaction between chiral species is reapplied in the modulation of the sublimation rate of d-(+)-camphor through the introduction of chiral milling additives. Full-Text PDF