瘦素
脂肪细胞
果糖
免疫系统
内科学
CD8型
内分泌学
生物
细胞毒性T细胞
T细胞
癌症研究
医学
免疫学
脂肪组织
生物化学
体外
肥胖
作者
Yuerong Zhang,Xiaoyan Yu,Rujuan Bao,Haiyan Huang,Chuanjia Gu,Qian-Ming Lv,Qiaoqiao Han,Xian Du,Xu-Yun Zhao,Youqiong Ye,Ren Zhao,Jiayuan Sun,Qiang Zou
出处
期刊:Cell Metabolism
[Elsevier]
日期:2023-12-01
卷期号:35 (12): 2107-2118.e6
被引量:8
标识
DOI:10.1016/j.cmet.2023.09.011
摘要
Summary
Fructose consumption is associated with tumor growth and metastasis in mice, yet its impact on antitumor immune responses remains unclear. Here, we show that dietary fructose modulates adipocyte metabolism to enhance antitumor CD8+ T cell immune responses and control tumor growth. Transcriptional profiling of tumor-infiltrating CD8+ T cells reveals that dietary fructose mediates attenuated transition of CD8+ T cells to terminal exhaustion, leading to a superior antitumor efficacy. High-fructose feeding initiates adipocyte-derived leptin production in an mTORC1-dependent manner, thereby triggering leptin-boosted antitumor CD8+ T cell responses. Importantly, high plasma leptin levels are correlated with elevated plasma fructose concentrations and improved antitumor CD8+ T cell responses in patients with lung cancer. Our study characterizes a critical role for dietary fructose in shaping adipocyte metabolism to prime antitumor CD8+ T cell responses and highlights that the fructose-leptin axis may be harnessed for cancer immunotherapy.
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