阿佩林
血管生成
外植体培养
细胞生物学
受体
内科学
化学
生物
医学
体外
生物化学
作者
Syeda Madiha,Bikram Sharma
出处
期刊:PubMed
日期:2023-01-01
卷期号:2023
被引量:1
标识
DOI:10.17912/micropub.biology.000886
摘要
APJ, a G-protein coupled receptor, regulates coronary angiogenesis in the developing mouse heart. However, the exact mechanism by which APJ regulates coronary angiogenesis from its dual ligands, ELABELA and APELIN, is unclear. Our study show that ELABELA and APELIN both stimulate angiogenic activities such as proliferation and sprouting outgrowth in explant cultures. We found APELIN to be a more robust angiogenic stimulant compared to ELABELA. When explant cultures were stimulated by both ligands together, we found that ELABELA repress the angiogenic activity of APELIN. Collectively, we show that ELABELA and APELIN regulate coronary angiogenesis in a competitive manner.
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