A Multi‐Functional Cascade Nanoreactor for Remodeling Tumor Microenvironment to Realize Mitochondria Dysfunction via ROS/Zn2+ Ions Overload

活性氧 肿瘤微环境 纳米反应器 化学 线粒体 生物物理学 谷胱甘肽 材料科学 癌症研究 生物化学 催化作用 生物 肿瘤细胞
作者
Longhai Jin,Shijie Zhou,Tianqi Zhang,Fengzhi Cui,Haijia Yu,Jianqiu Wang,Meng Wu,Yinghui Wang,Shuyan Song,Songtao Zhang,Hongjie Zhang,Jianhua Liu
出处
期刊:Small [Wiley]
标识
DOI:10.1002/smll.202408639
摘要

Abstract Combining chemo/photodynamic therapy (CDT/PDT) to generate highly harmful reactive oxygen species and cause mitochondria dysfunction is considered a potential strategy to improve the efficiency of anticancer treatment. However, within tumor, the relatively deficient concentration of H 2 O 2 , hypoxic microenvironment, and overexpressed reduced glutathione (GSH) seriously suppress the efficacy of dynamic therapy. Herein, a multi‐functional cascade nanoreactor, bovine serum albumin modified ZnO 2 @CeO 2 ‐ICG, is reported for remodeling tumor microenvironment (TME) to boost dynamic therapy and realize mitochondria dysfunction via reactive oxygen species (ROS) storm/Zn 2+ ions overload. Within TME, ZnO 2 decomposed into exogenous H 2 O 2 and Zn 2+ ion. The dual enzyme‐like CeO 2 catalyzes the increased H 2 O 2 into ·OH and oxygen molecules respectively, and then the oxygen molecules are translated into 1 O 2 by indocyanine green (ICG) under 808 nm light irradiation to boost PDT. The effective consumption of GSH through the reduction of Ce(IV) ions not only regenerates Ce(III) ions to enhance the efficiency of CDT but also efficaciously alleviates the elimination of ROS generated by dynamic therapy to further improve dynamic therapeutic efficiency. So the improved ROS level under remodeling TME and Zn 2+ ions acutely lead to mitochondria dysfunction to boost the efficiency of antitumor treatment. Thus, developing functional nanoreactors that enable remodeling TME provides a potential strategy to enhance the efficiency of dynamic therapy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
桐桐应助小伊采纳,获得10
刚刚
1秒前
安琪发布了新的文献求助10
1秒前
dada完成签到,获得积分10
1秒前
泡泡球发布了新的文献求助10
1秒前
2秒前
dlexdn发布了新的文献求助10
2秒前
Orange应助luct采纳,获得10
2秒前
沉静哲瀚发布了新的文献求助10
2秒前
8R60d8应助zzh12138采纳,获得10
2秒前
Ava应助小王采纳,获得30
3秒前
3秒前
科研通AI2S应助高山采纳,获得10
4秒前
小刘天下第一好完成签到,获得积分10
4秒前
dllz完成签到,获得积分10
4秒前
标致惋庭发布了新的文献求助10
5秒前
秋刀鱼完成签到,获得积分10
5秒前
5秒前
WEIFENG完成签到,获得积分10
6秒前
CHOSEN1完成签到,获得积分10
7秒前
顾矜应助楠楠2001采纳,获得10
7秒前
Endlessway应助健壮的板凳采纳,获得50
7秒前
36456657应助小星星采纳,获得10
8秒前
重要问筠完成签到,获得积分10
8秒前
培乐多完成签到,获得积分10
8秒前
Charming发布了新的文献求助20
8秒前
情怀应助安琪采纳,获得10
8秒前
9秒前
披萨红应助andycho采纳,获得10
9秒前
蓝胖子应助www采纳,获得30
9秒前
9秒前
淡定的忆山完成签到,获得积分10
9秒前
10秒前
10秒前
10秒前
10秒前
Wesley完成签到,获得积分10
10秒前
慕青应助qingxinhuo采纳,获得10
11秒前
11秒前
11秒前
高分求助中
歯科矯正学 第7版(或第5版) 1004
SIS-ISO/IEC TS 27100:2024 Information technology — Cybersecurity — Overview and concepts (ISO/IEC TS 27100:2020, IDT)(Swedish Standard) 1000
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Semiconductor Process Reliability in Practice 720
GROUP-THEORY AND POLARIZATION ALGEBRA 500
Mesopotamian divination texts : conversing with the gods : sources from the first millennium BCE 500
Days of Transition. The Parsi Death Rituals(2011) 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3231938
求助须知:如何正确求助?哪些是违规求助? 2878924
关于积分的说明 8208328
捐赠科研通 2546436
什么是DOI,文献DOI怎么找? 1375933
科研通“疑难数据库(出版商)”最低求助积分说明 647489
邀请新用户注册赠送积分活动 622660