A novel electrochemical sensing platform based on covalent organic frameworks/WC/NH2-MWCNT for highly selective determination of acetaminophen and 4-aminophenol

In this article, a novel and simple electrochemical sensing platform has been developed for the simultaneous and sensitive determination of acetaminophen (ACOP) and 4-aminophenol (4-AP). The porous covalent organic frameworks (COFs) material with β-ketoenamine-linkage was successfully synthesized via 1,3,5-triformylphloroglucinol (TFP) and 2,6-diaminoanthraquinone (DAAQ) and named as TFP-DAAQ-COF. High conductivity walnut shells-derived carbon (WC), amine-functionalized multi-walled carbon nanotubes (NH2-MWCNTs) with multiple active sites and TFP-DAAQ-COF were combined to obtain composite materials, which were used to modify bare glass carbon electrodes (GCE) and realize the electrochemical analysis of ACOP and 4-AP. The experiments showed that the composite electrode had a strong synergistic effect and exhibited a good electrocatalytic oxidation ability for the two target analytes. The linearity ranges of ACOP and 4-AP were 0.5 ∼ 200 μM and 1.0 ∼ 250 μM, respectively and the detection limits (S/N = 3) were 0.12 μM and 0.18 μM. In addition, the sensor showed acceptable reproducibility, stability and excellent selectivity. The recovery was satisfactory, when it was used to analyze the contents of ACOP and 4-AP in real samples, indicating that the sensor was feasible in practical applications.