光热治疗
纳米棒
表面等离子共振
光热效应
纳米技术
光纤
癌细胞
适体
循环肿瘤细胞
材料科学
化学
纳米颗粒
聚合
癌症
转移
光学
聚合物
分子生物学
物理
医学
内科学
复合材料
生物
作者
Xinyu Kong,Mingyue Li,Wei Xiao,Yongxin Li,Zewei Luo,Jiwei Shen,Yixiang Duan
出处
期刊:Talanta
[Elsevier]
日期:2024-06-17
卷期号:278: 126381-126381
被引量:2
标识
DOI:10.1016/j.talanta.2024.126381
摘要
Circulating tumor cell (CTC) in the blood is the main cause of cancer metastasis for death in cancer patients. It is extremely important for cancer diagnosis at an early stage and treatment to simultaneously detect and kill the CTCs. In this work, a new hybridized nanolayer, namely gold nanoparticle/gold nanorods@ Polydopamine (AuNPs/AuNRs@PDA), was coated on the Ω-shaped fiber optics (Ω-FO) for localized surface plasmonic resonance (LSPR) to perform tumor cell sensing and photothermal treatment (PTT). The PDA nanolayer was formed on a bare fiber optic through the self-polymerization of dopamine under mild conditions. The AuNRs and AuNPs were absorbed on the surface of the PDA nanolayer to form a hybridized nanolayer. The hybridized nanolayer-modified Ω-FO LSPR exhibited a high refractive index sensitivity (RIS) of 37.59 (a.u/RIU) and photothermal conversion efficiency. After being modified with the recognition element of aptamer, the Ω-FO LSPR was used to develop a sensitive and specifical tumor cell sensing. Under the irradiation of near-infrared light (NIR) laser, the Ω-FO LSPR can kill the captured tumor cells with the apoptotic/necrotic rate of 62.6 % and low side-effect for the nontarget cells. The FO LSPR sensor realized the dual functions of CTC sensing and PTT, which provided a new idea for the early diagnosis and treatment of cancer.
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