The responses of different dosages of egg consumption on blood lipid profile: An updated systematic review and meta‐analysis of randomized clinical trials

Journal of Food BiochemistryVolume 44, Issue 8 e13263 FULL ARTICLE The responses of different dosages of egg consumption on blood lipid profile: An updated systematic review and meta-analysis of randomized clinical trials Masoumeh Khalighi Sikaroudi, Masoumeh Khalighi Sikaroudi orcid.org/0000-0002-1829-4591 Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, IranSearch for more papers by this authorSepideh Soltani, Sepideh Soltani orcid.org/0000-0002-1591-2569 Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, IranSearch for more papers by this authorRoya Kolahdouz-Mohammadi, Roya Kolahdouz-Mohammadi orcid.org/0000-0001-6117-1143 Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, IranSearch for more papers by this authorZachary Stephen Clayton, Zachary Stephen Clayton Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USASearch for more papers by this authorMaria Luz Fernandez, Maria Luz Fernandez orcid.org/0000-0002-1835-0792 Department of Nutirional Sciences, University of Connecticut, Storrs, CT, USASearch for more papers by this authorFatemeh Varse, Fatemeh Varse orcid.org/0000-0002-6165-4177 Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, IranSearch for more papers by this authorFarzad Shidfar, Corresponding Author Farzad Shidfar [email protected] orcid.org/0000-0002-3179-0610 Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran Correspondence Farzad Shidfar, Department of Nutrition, School of Public Health, Iran University of Medical Sciences, 1449614535, Tehran, Iran. Email: [email protected]Search for more papers by this author Masoumeh Khalighi Sikaroudi, Masoumeh Khalighi Sikaroudi orcid.org/0000-0002-1829-4591 Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, IranSearch for more papers by this authorSepideh Soltani, Sepideh Soltani orcid.org/0000-0002-1591-2569 Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, IranSearch for more papers by this authorRoya Kolahdouz-Mohammadi, Roya Kolahdouz-Mohammadi orcid.org/0000-0001-6117-1143 Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, IranSearch for more papers by this authorZachary Stephen Clayton, Zachary Stephen Clayton Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USASearch for more papers by this authorMaria Luz Fernandez, Maria Luz Fernandez orcid.org/0000-0002-1835-0792 Department of Nutirional Sciences, University of Connecticut, Storrs, CT, USASearch for more papers by this authorFatemeh Varse, Fatemeh Varse orcid.org/0000-0002-6165-4177 Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, IranSearch for more papers by this authorFarzad Shidfar, Corresponding Author Farzad Shidfar [email protected] orcid.org/0000-0002-3179-0610 Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran Correspondence Farzad Shidfar, Department of Nutrition, School of Public Health, Iran University of Medical Sciences, 1449614535, Tehran, Iran. Email: [email protected]Search for more papers by this author First published: 11 June 2020 https://doi.org/10.1111/jfbc.13263Citations: 8Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Diverse notions exist regarding egg intake, which is one of the main sources of dietary cholesterol, and its effect on blood lipids. We conducted this study to update the previous meta-analysis for their flaw in calculated effect size. PubMed, Scopus, ISI, and Cochrane were searched up to April 2019, for relevant randomized controlled clinical trials. Mean changes in total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), triglyceride (TG), very low-density lipoprotein cholesterol (VLDL-C), LDL-C/HDL-C, TC/HDL-C, apolipoprotein (apo)A1, and apoB100 were assessed. Meta-analysis of 66 RCTs with 3,185 participants revealed that egg consumption can significantly increase TC, LDL-C, HDL-C, TC/HDL-C, apoA1/and B100, but there was no significant effect on other serum lipids. Dose-response analysis showed a linear effect for TC, HDL-C, ApoA1, ApoB100, and nonlinear for LDL-C, and TC/HDL-C. In conclusion, intake of more than one egg daily in less than 12 weeks may increase some blood lipids without any changes in the ratio of LDL-C/HDL-C. Practical applications There are controversies reports for egg intake, which is one of the main sources of dietary cholesterol. This study provides comprehensive information about the effect of the number of eggs consumed per day (dietary cholesterol) on blood lipids for nutritionists, physicians, researchers, and the general population. In this regard, our results indicated that there is a linear correlation between consumption of greater than one egg per day in a short time (no long time) and increasing lipid profiles which may increase the risk of cardiovascular diseases. However, consumption of one egg daily can be safe and this can be a useful recommendation for prevention of cardiovascular disease and promotion of healthy life which indeed are the potential or actual uses of this research. CONFLICT OF INTEREST The authors declared that there were no conflicts of interest. Citing Literature Supporting Information Filename Description jfbc13263-sup-0001-Supinfo.docxWord document, 8.4 MB Supplementary Material Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume44, Issue8August 2020e13263 RelatedInformation