糖酵解
激酶
生物
磷酸甘油酸激酶
血管生成
癌症研究
三磷酸腺苷
转移
DNA复制
酶
癌细胞
自噬
细胞生物学
生物化学
癌症
DNA
遗传学
细胞凋亡
作者
He Li,Xingchen Wang,Peibo Shen,Yingqian Ni,Xiuzhen Han
标识
DOI:10.1016/j.ejphar.2022.174835
摘要
Phosphoglycerate kinase 1 (PGK1) is an essential enzyme that catalyzes adenosine 5'-triphosphate (ATP) production in aerobic glycolysis. In addition to regulating cell metabolism, PGK1 is involved in multiple biological activities, including angiogenesis, mediated autophagy starting, binding of plasminogen, the DNA replication and repair, the proliferation and metastasis of tumor cells, cell invasion (a part of the flagellar axoneme and viral replication and it occurs mainly in protists), and is also associated with resistance to chemotherapy and prognosis of cancer patients. In this review, we focus on the basic functions of PGK1 and the relationship between PGK1 and different diseases, indicating that PGK1 has a broad application prospect to find a potential biomarker for tumor prognosis and an effective inhibitor.
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