Recent advances in synthesis of quinazoline‐2,4(1H,3H)‐diones: Versatile building blocks in N‐heterocyclic compounds

Abstract Quinazoline‐2,4( 1H,3H )‐dione is a significant class of N ‐fused heterocyclic with a wide range of biological functions, including anti‐HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti‐inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities, and other activities, and has attracted great attention in organic and medicinal chemistry. As a result, all chemists and pharmaceutical chemists must be aware of many methods to make quinazoline‐2,4( 1H,3H )‐dione. This review paper focuses on various methods for producing quinazoline‐2,4( 1H,3H )‐diones, such as green methods and homogeneous or heterogeneous catalysts from various precursors under varied conditions.