单宁酸
自愈水凝胶
伤口愈合
止血
溶血
化学
抗氧化剂
体内
生物相容性
生物医学工程
材料科学
抗菌活性
高分子化学
生物化学
有机化学
外科
遗传学
免疫学
细菌
生物技术
生物
医学
作者
Zongbao Zhou,Jiangwei Xiao,Shuwen Guan,Zhijie Geng,Ruifang Zhao,Botao Gao
标识
DOI:10.1016/j.carbpol.2022.119235
摘要
Manufacturing facile and low-cost wound dressings that simultaneously meet the needs of the entire repair process remains the major challenge of effective wound healing. Herein, a series of curdlan-tannic acid hybrid hydrogels were successfully fabricated through the annealing technique. Notedly, when the mixing weigh ratio was 1:1, the hydrogel exhibited excellent physicochemical properties, including swellability, degradability, water retention, porosity, and rheology. Additionally, the hydrogel did not display significant cytotoxicity to fibroblasts and the hemolysis rate at 12 h was 3%. Interestingly, the hybrid hydrogel showed multifunctional properties, including remarkable antioxidant, antibacterial, and rapid hemostasis effects reduce blood loss by 0.35 g, that were achieved through the temperature-dependent release of tannic acid. Moreover, a full-thickness skin defect animal model was used to verify that the multifunctional hydrogel could accelerate wound healing in vivo. These results suggest that this hybrid hydrogel is a promising candidate for the clinical treatment of full-thickness wounds.
科研通智能强力驱动
Strongly Powered by AbleSci AI