光热治疗
材料科学
乙二醇
两亲性
生物相容性
超分子化学
纳米技术
分子
水溶液
光化学
化学工程
聚合物
共聚物
有机化学
化学
工程类
复合材料
冶金
作者
Yigang Wang,Guomin Xia,Manman Tan,Mingda Wang,Yingzhong Li,Hongming Wang
标识
DOI:10.1002/adfm.202113098
摘要
Abstract Understanding and implementing the ordered supramolecular assembly in organic photothermal materials is challenging, yet significant, for photothermal performance enhancement. Herein, an amphipathic squaraine dye (PSQ) with a poly (ethylene glycol) chain attached as a hydrophilic anchor is synthesized. In aqueous solution, PSQ spontaneously self‐assembles into uniform nanospheres (PSQ‐NSs) with well‐defined H‐dimeric substructures. Molecular dynamics simulations are conducted to illustrate the self‐assembly process. Reorganization energy calculations show that nonradiative decay is accelerated by H‐dimeric PSQ low‐frequency out‐of‐plane vibrational modes, which enables a rapid dissipation of excited‐state energy to heat. As such, the resultant H‐dimeric PSQ‐NSs exhibit ultrahigh photothermal conversion efficiency (81.2%) under laser irradiation (0.3 W cm −2 , 808 nm) in water. In vitro and in vivo evaluations confirm their high stability, biocompatibility, tumor accumulation, and efficient tumor inhibition in photothermal therapy. It is expected that the self‐assembling H‐dimers will become a unique platform for the precise designing of small‐molecule PTAs for future clinical PTT applications.
科研通智能强力驱动
Strongly Powered by AbleSci AI