诱导多能干细胞
重编程
SOX2
KLF4公司
体细胞
疾病
生物
神经科学
干细胞
帕金森病
药物发现
生物信息学
作者
Yiran Xu,Shuxia Wang,Ping Zhu
出处
期刊:Current stem cell research & therapy
[Bentham Science]
日期:2022-04-26
摘要
Induced pluripotent stem cells (iPSCs) are a type of pluripotent stem cells induced by somatic cells. It was found that differentiated cells could be reprogrammed to a pluripotent state by the expression of the four transcription factors such as Oct3/4, Sox2, c-Myc, and Klf4. This technology can be applied to reprogramme the patient cells into iPSCs which further be induced into research-required cells or tissues. Nowadays, a great number of reprogramming methods and various types of somatic cells can be used to produce iPSCs. The advance of this technology provides a promising pathway to disease models building, drug development and the corresponding cell-based therapy. Alzheimer's diseases (AD) and Parkinson's diseases (PD) are complex diseases affected by many factors including genetic and environmental factors. Until now, there are no effective treatments to reverse these diseases because the pathogenesis of these complex diseases is still not well understood. One important reason is that the existing disease model cannot fully recapitulate the pathologies of these multifactorial associated diseases. And iPSCs have the potential to resolve this difficulty. In this review, we discuss the application progress of iPSCs in AD and PD including the disease modeling, drug development and cell-based therapies.
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