惠普雷
惠普尔病
惠普尔病
疾病
免疫学
马车
无症状的
免疫系统
生物
医学
病理
腹腔疾病
肠道吸收不良
作者
Asma Boumaza,Eya Ben Azzouz,Jeffrey Arrindell,Hubert Lépidi,Soraya Mezouar,Benoît Desnues
标识
DOI:10.1016/s1473-3099(22)00128-1
摘要
Whipple's disease is a chronic and systemic disease caused by the Gram-positive bacterium Tropheryma whipplei that primarily affects the gastrointestinal tract. Data from the last two decades have substantially increased our knowledge of the spectrum and our understanding of T whipplei infections. Although T whipplei seems ubiquitously present in the environment, Whipple's disease itself is very rare. Remarkably, primary infections can be symptomatic, but most cases result in bacterial clearance and seroconversion. However, some individuals are unable to clear the bacterium leading to persistence and asymptomatic carriage. In very rare cases, which might be associated with a subtle immune defect, T whipplei replication is uncontrolled and manifests as classical Whipple's disease or T whipplei localised infections. In this review, we provide a comprehensive outline of T whipplei infection, including the epidemiology, clinical manifestations, diagnosis, and treatment. We also provide an up-to-date overview of our understanding of the host immune response and pathophysiology and discuss future research avenues to resolve the lacking pieces of the puzzle of T whipplei infections.
科研通智能强力驱动
Strongly Powered by AbleSci AI