生物
细胞毒性T细胞
免疫系统
存储单元
抗原
细胞生物学
基因表达谱
T细胞
免疫学
细胞分化
CD8型
基因表达
记忆T细胞
基因
遗传学
体外
物理
晶体管
量子力学
电压
作者
Susan M. Kaech,Scott E. Hemby,Ellen N. Kersh,Rafi Ahmed
出处
期刊:Cell
[Elsevier]
日期:2002-12-01
卷期号:111 (6): 837-851
被引量:949
标识
DOI:10.1016/s0092-8674(02)01139-x
摘要
How and when memory T cells form during an immune response are long-standing questions. To better understand memory CD8 T cell development, a time course of gene expression and functional changes in antigen-specific T cells during viral infection was evaluated. The expression of many genes continued to change after viral clearance in accordance with changes in CD8 T cell functional properties. Even though memory cell precursors were present at the peak of the immune response, these cells did not display hallmark functional traits of memory T cells. However, these cells gradually acquired the memory cell qualities of self-renewal and rapid recall to antigen suggesting the model that antigen-specific CD8 T cells progressively differentiate into memory cells following viral infection.
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