化学
抗菌剂
环加成
脱羧
吡咯
醛
细菌
人类病原体
化学合成
致病菌
分子内力
抗菌剂
1,3-偶极环加成
抗菌活性
立体化学
组合化学
有机化学
体外
抗生素
生物化学
催化作用
基因
生物
遗传学
作者
S. Purushothaman,R. Prasanna,P. Niranjana,R. Raghunathan,S. Nagaraj,R. Rengasamy
标识
DOI:10.1016/j.bmcl.2010.10.073
摘要
Synthesis of a series of novel hexahydrochromenopyrrole analogues has been accomplished through an intramolecular 1,3-dipolar cycloaddition (1,3-DC reaction) of azomethine ylides, generated by the aldehyde induced decarboxylation of secondary amino acids. These compounds were screened for antibacterial and antifungal activities against six human pathogenic bacteria and three human pathogenic fungi and found to have good antimicrobial properties against most of the microorganisms.
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