区域选择性
化学
亚胺
烷烃
产量(工程)
三元运算
无水的
反应性(心理学)
有机化学
计算化学
药物化学
催化作用
材料科学
医学
替代医学
病理
计算机科学
冶金
程序设计语言
作者
Mohamed S. Mohamed Ahmed,Ahmed E. M. Mekky,Sherif M. H. Sanad
标识
DOI:10.1007/s13738-023-02851-5
摘要
Abstract A three-component approach was conducted to adeptly prepare a new series of ( Z )-bis( N -phenylthiazol-2(3 H )-imines. The newly synthesized compounds were prepared by refluxing a ternary mixture of phenyl isothiocyanate, the suitable α-bromoketones, and alkane-linked diamines in ethanol. Reaction conditions were optimized by comparing the yield of the final product under various bases, solvents, temperatures, and base-to-starting-materials molar ratios. The intended hybrids were produced with 85–96% yields while using ethanol at 80 °C for 3–5 h in the presence of anhydrous sodium acetate. The ascribed configuration of new products as well as the regioselectivity of the one-pot reaction were confirmed using both spectral data (1D and 2D NMR) and DFT-calculation techniques. Graphical abstract
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