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H2O2/pH Dual-Responsive Biomimetic Nanoenzyme Drugs Delivery System for Enhanced Tumor Photodynamic Therapy

吲哚青绿 光动力疗法 肿瘤微环境 过氧化氢酶 药物输送 光毒性 光敏剂 化学 肿瘤缺氧 过氧化氢 生物物理学 癌症研究 氧化应激 药理学 纳米技术 材料科学 光化学 生物化学 医学 病理 肿瘤细胞 生物 外科 放射治疗 体外 有机化学
作者
Xinyuan Li,Qing Ji,Chao Yan,Ziyu Zhu,Zhihui Yan,Ping Chen,Sheng Wang,Li Song
出处
期刊:Nanoscale Research Letters [Springer Nature]
卷期号:17 (1) 被引量:11
标识
DOI:10.1186/s11671-022-03738-9
摘要

Abstract Phototherapy has been recognized as a photochemical process to treat tumor via induce cancer cells necrosis and death, with minimal invasiveness, higher selectivity, and few side effects. However, the therapy effects of phototherapy are often compromised by the hypoxia, high levels of hydrogen peroxide, and glutathione of tumor microenvironment (TME). Therefore, we constructed a catalase-like activity bionic metal–organic framework drugs delivery system (FA-EM@MnO 2 /ZIF-8/ICG) with tumor microenvironment controllable releasing. In this system, photosensitizer indocyanine green (ICG) was introduced into zeolite imidazole salt skeleton 8 (ZIF-8) by one-step methods, forming ZIF-8/ICG nano-platform, which can effectively avoid ICG-induced phototoxicity and aggregation-induced quenching during transport. MnO 2 with catalase-like activity was coated on the surface of ZIF-8/ICG nano-platform, which made it have the ability of self-supplying O 2 under the condition of H 2 O 2 in TME. Exposure under near-infrared light can alleviate the anoxic TME, thus improving the phototherapy efficiency. In addition, folate-functionalized erythrocyte membrane is coated on the surface of MnO 2 /ZIF-8/ICG, which can endow FA-EM@MnO 2 /ZIF-8/ICG with the ability of targeted drug administration and immune elimination avoidance. Therefore, FA-EM@MnO 2 /ZIF-8/ICG nano-platform has the catalase-like activity, which can alleviate the oxidative stress state of TME and provide a beneficial environment for photodynamic therapy of tumor.
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