抗菌剂
化学
粪肠球菌
槲皮素
传统医学
橙皮苷
最小抑制浓度
细菌
生物
植物
金黄色葡萄球菌
微生物学
生物化学
抗氧化剂
遗传学
医学
病理
替代医学
作者
Irma Mahmutović-Dizdarević,Aner Mešić,Anesa Jerković-Mujkić,Belma Žujo,Monia Avdić,Mirsada Hukić,Elma Omeragić,Amar Osmanović,Selma Špirtović‐Halilović,Sarah Ahmetovski,Samra Mujkanović,Emina Pramenković,Mirsada Salihović
出处
期刊:Fitoterapia
[Elsevier]
日期:2024-09-01
卷期号:177: 106114-106114
标识
DOI:10.1016/j.fitote.2024.106114
摘要
Morus alba L. is a plant with a long history of dietary and medicinal uses. We hypothesized that M. alba possesses a significant biological potential. In that sense, we aimed to generate the chemical, antimicrobial, toxicological, and molecular profile of M. alba leaf and fruit extracts. Our results showed that extracts were rich in vitamin C, phenols, and flavonoids, with quercetin and pterostilbene concentrated in the leaf, while fisetin, hesperidin, resveratrol, and luteolin were detected in fruit. Extracts exhibited antimicrobial activity against all tested bacteria, including multidrug-resistant strains. The widest inhibition zones were in Staphylococcus aureus ATCC 33591. The values of the minimum inhibitory concentration ranged from 15.62 μg/ml in Enterococcus faecalis to 500 μg/ml in several bacteria. Minimum bactericidal concentration ranged from 31.25 μg/ml to 1000 μg/ml. Extracts impacted the biofilm formation in a concentration-dependent and species-specific manner. A significant difference in the frequency of nucleoplasmic bridges between the methanolic extract of fruit (0.5 μg/ml, 1 μg/ml, 2 μg/ml), as well as for the frequency of micronuclei between ethanolic extract of leaf (2 μg/ml) and the control group was observed. Molecular docking suggested that hesperidin possesses the highest binding affinity for multidrug efflux transporter AcrB and acyl-PBP2a from MRSA, as well as for the SARS-CoV-2 Mpro. This study, by complementing previous research in this field, gives new insights that could be of great value in obtaining a more comprehensive picture of the Morus alba L. bioactive potential, chemical composition, antimicrobial and toxicological features, as well as molecular profile.
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