脂肪肝
六烯酸
脂质代谢
内科学
磷脂酰丝氨酸
内分泌学
脂肪酸代谢
代谢组学
脂肪酸
多不饱和脂肪酸
新陈代谢
免疫印迹
化学
脂肪性肝炎
生物化学
生物
磷脂
医学
疾病
生物信息学
膜
基因
作者
Honglei Zhang,Shanshan Tian,Qiaoling Zhao,Youjia Xu,Lijun Bi,Jian Su,Yunping Tang
标识
DOI:10.1016/j.procbio.2023.11.005
摘要
To investigate the regulatory mechanism of docosahexaenoic acid-enriched phosphatidylserine (DHA-PS) on high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD). The murine model was established by HFD or HFD combined with DHA-PS (100 mg/kg) administration for 10 weeks. DHA-PS administration notably improved HFD-induced abnormalities of liver function, lipid indices, inflammatory markers, and oxidative stress. In addition, based on non-targeted metabolomics, HFD notably disrupted the amino acid metabolism and fatty acid metabolism in murine liver tissue, while DHA-PS notably regulated the amino acid metabolism and PPAR signaling pathway to alleviate HFD-induced liver metabolic disorder. Moreover, results from Western blot and immunohistochemical analysis confirmed that DHA-PS alleviated HFD-induced NAFLD by regulating lipid metabolism and restraining the TLR4/NF-κB pathway. The results obtained suggest that DHA-PS might be used as a potential dietary supplement for alleviating HFD-induced NAFLD.
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