化学
亚胺
连二亚硫酸钠
串联
分子内力
硝基
废止
试剂
组合化学
功能群
药物化学
有机化学
催化作用
复合材料
材料科学
聚合物
烷基
作者
Joydev K. Laha,Pankaj Gupta,Amitava Hazra
标识
DOI:10.1021/acs.joc.3c01844
摘要
A one-pot, tandem reductive annulation of 2-nitrobenzenesulfonamides with aldehydes to the synthesis of substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxides in the presence of sodium dithionite (Na2S2O4) is reported under mild conditions. The method involves in situ reduction of the nitro group followed by condensation with aldehydes to form an imine, which upon subsequent intramolecular cyclization forms the product under one-pot conditions. The protocol features use of inexpensive Na2S2O4 as the exclusive reagent, appreciable functional group tolerance, broad substrate scope, high product yields, and scalability.
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