微泡
胰腺癌
转移
外体
癌症研究
血管生成
生物
小RNA
上皮-间质转换
非编码RNA
抗药性
恶性肿瘤
核糖核酸
细胞外基质
癌症
医学
病理
细胞生物学
基因
微生物学
生物化学
遗传学
作者
Gengyu Sha,Wenjie Zhang,Zhengting Jiang,Qianqian Zhao,Daorong Wang,Dong Tang
标识
DOI:10.1016/j.ijbiomac.2024.130149
摘要
Pancreatic cancer is the most fatal malignancy worldwide. Once diagnosed, most patients are already at an advanced stage because of their highly heterogeneous, drug-resistant, and metastatic nature and the lack of effective diagnostic markers. Recently, the study of proliferation, metastasis, and drug resistance mechanisms in pancreatic cancer and the search for useful diagnostic markers have posed significant challenges to the scientific community. Exosomes carry various biomolecules (DNA, non-coding RNAs (ncRNAs), proteins, and lipids) that mediate communication between tumors and other cells. ncRNAs can be transported through exosomes to numerous relevant receptor cells and regulate local epithelial-mesenchymal transition (EMT) in tumor tissue, proliferation, drug resistance, and the establishment of pre-metastatic ecological niches in distant organs. In summary, exosomal ncRNAs promote tumor cell proliferation, invasion, and metastasis through multiple EMT, immunosuppression, angiogenesis, and extracellular matrix remodeling pathways. Moreover, we discuss the significant therapeutic significance of exosomal ncRNAs as PC biomarkers.
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