材料科学
胶粘剂
复合材料
软骨
自愈水凝胶
纳米纤维
生物相容性
多孔性
纤维素
抗剪强度(土壤)
固定(群体遗传学)
细菌纤维素
化学工程
高分子化学
化学
解剖
图层(电子)
工程类
土壤科学
土壤水分
基因
冶金
医学
生物化学
环境科学
作者
Jiacheng Zhao,Alina Kirillova,Cambre Kelly,Heng Xu,William J. Koshut,Feichen Yang,Ken Gall,Benjamin J. Wiley
标识
DOI:10.1002/adhm.202001119
摘要
Abstract The repair of a cartilage lesion with a hydrogel requires a method for long‐term fixation of the hydrogel in the defect site. Attachment of a hydrogel to a base that allows for integration with bone can enable long‐term fixation of the hydrogel, but current methods of forming bonds to hydrogels have less than a tenth of the shear strength of the osteochondral junction. This communication describes a new method, nanofiber‐enhanced sticking (NEST), for bonding a hydrogel to a base with an adhesive shear strength three times larger than the state‐of‐the‐art. An example of NEST is described in which a nanofibrous bacterial cellulose sheet is bonded to a porous base with a hydroxyapatite‐forming cement followed by infiltration of the nanofibrous sheet with hydrogel‐forming polymeric materials. This approach creates a mineralized nanofiber bond that mimics the structure of the osteochondral junction, in which collagen nanofibers extend from cartilage into a mineralized region that anchors cartilage to bone.
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