Molecular basis and biological function of variability in spatial genome organization

Heterogeneity in genome organization How the genome is organized in the three-dimensional space of the cell nucleus influences the activity of gene expression. Finn and Misteli review features of genome architecture and cell- and allele-specific variability in spatial genome organization. They also connect stochasticity in gene transcription and variability in genome organization and discuss the functional consequences of genome variability at the cell and population levels in development and disease. Science , this issue p. eaaw9498