The application of serum total IgE and fractional exhaled nitric oxide levels in guiding asthma-chronic obstructive pulmonary disease overlap syndrome

Objective To provide clues for the diagnosis standard, laboratory examination and pathological mechanism of asthma and chronic obstructive pulmonary disease overlap syndrome(ACOS) by detecting the levels of serum total IgE, fractional exhaled nitric oxide (FeNO) and peripheral blood oxyphil cells in asthma, chronic obstructive pulmonary disease (C0PO) and ACOS. Methods A prospective randomized trial based on hospital was conducted. According to the diagnostic criteria and inclusion criteria, 40 asthma patients (asthma group), 25 cases of patients with COPD (COPD group) and 37 cases of ACOS patients (ACOS group) were collected continuously, and 40 healthy persons (healthy control group) were as the research object. General data and biochemical indexes were tested in each group. The levels of serum total IgE, FeNO and peripheral blood oxyphil cells in each group were observed and compared. The correlation between serum total IgE and other biochemical parameters were analyzed by Pearson correlation analysis. Results The level of total serum IgE in asthma group was significantly higher than that in other groups (P 0.05). The level of FeNO in four groups had significant difference (P < 0.05), and the level of FeNO in ACOS group and asthma group had significant difference compared with that of COPD group (P < 0.05). The level of peripheral blood oxyphil cells in asthma group, ACOS group, COPD group was significantly higher than that in healthy control group (P < 0.05), and the change of ACOS group was the best obviously. Conclusions Serum total IgE, FeNO and peripheral blood oxyphil cells are specific detection index in ACOS. Combined detection can help to identify ACOS, asthma and COPD, also reveal the presence of airway inflammation in the pathogenesis of ACOS, and can provide the basis for clinical diagnosis, treatment and prevention. Key words: Oxyphil cells; Asthma-chronic obstructive pulmonary disease overlap syndrome; Serum total IgE; Fractional exhaled nitric oxide