A narrative review of platelet-rich plasma (PRP) in reproductive medicine

生殖医学 医学 卵巢储备 不育 奇纳 保持生育能力 妇科 怀孕 辅助生殖技术 富血小板血浆 妊娠率 子宫内膜 活产 血小板 生物 生育率 内科学 精神科 环境卫生 遗传学 心理干预 人口
作者
Fady I. Sharara,Latashia-Lika Lelea,Sara Rahman,Jordan S. Klebanoff,Gaby Moawad
出处
期刊:Journal of Assisted Reproduction and Genetics [Springer Nature]
卷期号:38 (5): 1003-1012 被引量:89
标识
DOI:10.1007/s10815-021-02146-9
摘要

Platelet-rich plasma (PRP) has become a novel treatment in various aspects of medicine including orthopedics, cardiothoracic surgery, plastic surgery, dermatology, dentistry, and diabetic wound healing. PRP is now starting to become an area of interest in reproductive medicine more specifically focusing on infertility. Poor ovarian reserve, menopause, premature ovarian failure, and thin endometrium have been the main areas of research. The aim of this article is to review the existing literature on the effects of autologous PRP in reproductive medicine providing a summation of the current studies and assessing the need for additional research.A literature search is performed using PubMed, MEDLINE, and CINAHL Plus to identify studies focusing on the use of PRP therapy in reproductive medicine. Articles were divided into 3 categories: PRP in thin lining, PRP in poor ovarian reserve, and PRP in recurrent implantation failure.In women with thin endometrium, the literature shows an increase in endometrial thickness and increase in chemical and clinical pregnancy rates following autologous PRP therapy. In women with poor ovarian reserve, autologous intraovarian PRP therapy increased anti-Mullerian hormone (AMH) levels and decreased follicle-stimulating hormone (FSH), with a trend toward increasing clinical and live birth rates. This trend was also noted in women with recurrent implantation failure.Limited literature shows promise in increasing endometrial thickness, increasing AMH, and decreasing FSH levels, as well as increasing chemical and clinical pregnancy rates. The lack of standardization of PRP preparation along with the lack of large randomized controlled trials needs to be addressed in future studies. Until definitive large RCTs are available, PRP use should be considered experimental.
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