微流控
离子
人类血液
电位滴定法
电化学
全血
频谱分析仪
化学
材料科学
分析化学(期刊)
光电子学
纳米技术
电极
色谱法
计算机科学
免疫学
生物
电信
生理学
物理化学
有机化学
作者
Joon‐Hyung Jin,Joon Kim,Sang Yong Lee,Samjin Choi,Chan Park,Nam Min
出处
期刊:Sensors
[MDPI AG]
日期:2018-01-01
卷期号:18 (1): 104-104
被引量:28
摘要
A fully integrated paper microfluidic electrochemical device equipped with three different cation permeable films is developed to determine blood ions (Cl−, Na+, K+, and Ca2+) at a time. These blood ions that are normally dissolved in the real human blood stream are essential for cell metabolisms and homeostasis in the human body. Abnormal concentration of blood ions causes many serious disorders. The optimized microfluidic device working without any external power source can directly and effectively separate human blood components, and subsequently detect a specific blood ion with minimized interference. The measured sensitivity to Cl−, K+, Na+, and Ca2+ are −47.71, 45.97, 51.06, and 19.46 in mV decade−1, respectively. Potentiometric responses of the microfluidic devices to blood serum samples are in the normal ranges of each cation, and comparable with responses from the commercial blood ion analyzer Abbott i-Stat.
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