Asperteramide A, an Unusual N‐Phenyl‐Carbamic Acid Methyl Ester Trimer Isolated from the Coral‐Derived Fungus Aspergillus Terreus

Asperteramide A, an unusual N ‐phenyl‐carbamic acid methyl ester trimer, was isolated and identified from the coral‐derived fungus Aspergillus terreus . The deceptive and indistinguishable NMR signals caused by three N ‐phenyl‐carbamic acid methyl ester subunits located in different spatial environments created great challenge for the identification of its planar structure, but recrystallization ultimately afforded a suitable crystal for the X‐ray diffraction experiment, which enabled its final structure determination. The plausible biosynthetic pathway of 1 mainly involved in the successive Friedel–Crafts reactions. Additionally, compound 1 showed significant antibacterial activity against seven microbial pathogens [ESBL‐producing Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae , methicillin‐resistant Staphylococcus aureus, Enterococcus faecalis, Candida albicans ] with MIC values ranging from 2 to 64 µg/mL.