Protective effects of β-glucan isolated from highland barley on ethanol-induced gastric damage in rats and its benefits to mice gut conditions

超氧化物歧化酶 丙二醛 胃肠道 盲肠 氧化应激 一氧化氮 葡聚糖 过氧化氢酶 人口 化学 食品科学 药理学 医学 内科学 生物化学 环境卫生
作者
Haihong Chen,Qixing Nie,Min Xie,Haoyingye Yao,Ke Zhang,Jingdong Yin,Shaoping Nie
出处
期刊:Food Research International [Elsevier]
卷期号:122: 157-166 被引量:47
标识
DOI:10.1016/j.foodres.2019.04.011
摘要

Gastrointestinal tract disease is a global health problem which affects a major part of the world population. In this study, the gastroprotective effects of β-glucan isolated from highland barley on ethanol-induced gastric damage in rats and its benefits to mice gut health were investigated. Biochemical and pathological analysis methods were adopted to evaluating the gastrointestinal tract protective of β-glucan isolated from highland barley. In the ulceration model, it was found that β-glucan treatment could mitigate the gastric lesions and gastric mucosal damage caused by ethanol, decrease the gastric ulcer index. Furthermore, β-glucan treatment alleviated the gastric oxidative stress injury in vehicle rats through increasing the activity of superoxide dismutase and catalase, decreasing the level of malondialdehyde. In addition, β-glucan treatment also could decrease the level of interleukin-6 and tumor necrosis factor alpha and increased level of prostaglandin E2, nitric oxide. In the mouse gut health promoting model, β-glucan treatment increased the colon length, faces water contents and the concentration of total short-chain fatty acids (SCFAs) both in mice colon and cecum. Taken together, these results may indicate that β-glucan isolated from highland barley exert protective effects on the gastrointestinal tract of laboratory rodents.
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