自噬
姜黄素
癌变
细胞应激反应
程序性细胞死亡
癌细胞
癌症
生物
细胞凋亡
癌症研究
细胞生物学
药理学
战斗或逃跑反应
生物化学
遗传学
基因
作者
Abolfazl Shakeri,Arrigo F.G. Cicero,Yunes Panahi,Mohammad Mohajeri,Amirhossein Sahebkar
摘要
Autophagy is a self-degradative process that plays a pivotal role in several medical conditions associated with infection, cancer, neurodegeneration, aging, and metabolic disorders. Its interplay with cancer development and treatment resistance is complicated and paramount for drug design since an autophagic response can lead to tumor suppression by enhancing cellular integrity and tumorigenesis by improving tumor cell survival. In addition, autophagy denotes the cellular ability of adapting to stress though it may end up in apoptosis activation when cells are exposed to a very powerful stress. Induction of autophagy is a therapeutic option in cancer and many anticancer drugs have been developed to this aim. Curcumin as a hydrophobic polyphenol compound extracted from the known spice turmeric has different pharmacological effects in both in vitro and in vivo models. Many reports exist reporting that curcumin is capable of triggering autophagy in several cancer cells. In this review, we will focus on how curcumin can target autophagy in different cellular settings that may extend our understanding of new pharmacological agents to overcome relevant diseases.
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