神经科学
被盖腹侧区
黑质
多巴胺
中缝核
致密部
电生理学
中缝
谷氨酸的
中脑
兴奋性突触后电位
被盖
脑干
抑制性突触后电位
血清素
生物
化学
受体
谷氨酸受体
多巴胺能
5-羟色胺能
中枢神经系统
生物化学
作者
G DIGIOVANNI,V DIMATTEO,Massimo Pierucci,Ennio Esposito
出处
期刊:Progress in Brain Research
日期:2008-01-01
卷期号:: 45-71
被引量:128
标识
DOI:10.1016/s0079-6123(08)00903-5
摘要
In this review, the most relevant data regarding serotonin (5-hydroxytryptamine, 5-HT)/dopamine (DA) interaction in the brain, as studied by both in vivo and in vitro electrophysiological methods, are reported and discussed. The bulk of neuroanatomical data available clearly indicate that DA-containing neurons in the brain receive a prominent innervation from 5-HT originating in the raphe nuclei of the brainstem. Furthermore, this modulation seems to be reciprocal; DA neurons innervate the raphe nuclei and exert a tonic excitatory effect on them. Compelling electrophysiological data show that 5-HT can exert complex effects on the electrical activity of midbrain DA neurons mediated by the various receptor subtypes. The main control seems to be inhibitory, this effect being more marked in the ventral tegmental area (VTA) as compared to the substantia nigra pars compacta (SNc). In spite of a direct effect of 5-HT by its receptors located on DA cells, 5-HT can modulate their activity indirectly, modifying gamma-amino-n-butyric acid (GABA)-ergic and glutamatergic input to the VTA and SNc. Although 5-HT/DA interaction in the brain has been extensively studied, much work remains to be done to clarify this issue. The recent development of subtype-selective ligands for 5-HT receptors will not only allow a detailed understanding of this interaction but also lead to development of new treatment strategies, appropriate for those neuropsychiatric disorders in which an alteration of the 5-HT/DA balance is supposed.
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