NAD+激酶
烟酰胺磷酸核糖转移酶
CD38
烟酰胺腺嘌呤二核苷酸
聚ADP核糖聚合酶
生物化学
烟酰胺单核苷酸
酶
辅因子
锡尔图因
骨骼肌
烟酰胺
新陈代谢
化学
生物
细胞生物学
聚合酶
内分泌学
干细胞
川地34
出处
期刊:Cells
[MDPI AG]
日期:2022-02-17
卷期号:11 (4): 710-710
被引量:11
标识
DOI:10.3390/cells11040710
摘要
Nicotinamide adenine dinucleotide (NAD) is a versatile chemical compound serving as a coenzyme in metabolic pathways and as a substrate to support the enzymatic functions of sirtuins (SIRTs), poly (ADP-ribose) polymerase-1 (PARP-1), and cyclic ADP ribose hydrolase (CD38). Under normal physiological conditions, NAD+ consumption is matched by its synthesis primarily via the salvage pathway catalyzed by nicotinamide phosphoribosyltransferase (NAMPT). However, aging and muscular contraction enhance NAD+ utilization, whereas NAD+ replenishment is limited by cellular sources of NAD+ precursors and/or enzyme expression. This paper will briefly review NAD+ metabolic functions, its roles in regulating cell signaling, mechanisms of its degradation and biosynthesis, and major challenges to maintaining its cellular level in skeletal muscle. The effects of aging, physical exercise, and dietary supplementation on NAD+ homeostasis will be highlighted based on recent literature.
科研通智能强力驱动
Strongly Powered by AbleSci AI