硝化作用
化学
炔烃
氧化磷酸化
芳基
组合化学
硝基
级联
有机化学
催化作用
生物化学
色谱法
烷基
作者
Liu-Yu Shen,Junnan Li,Jianguo Feng,Pinhua Li,Wenchao Yang
标识
DOI:10.1002/adsc.202200722
摘要
Abstract A K 2 S 2 O 8 ‐promoted nitration/spirocyclization of biaryl ynones using inexpensive NaNO 2 as nitro source has been described. This cascade reaction is triggered by nitration of alkyne and followed by 6‐exo‐trig spirocyclization, dearomatization, forming the NO 2 ‐containing spiro[5.5]trienones in 63–85% yields. The present reaction also provides a practical method for the synthesis of nitrated indenones and thioflavones with 58–85% yields. magnified image
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