被盖腹侧区
神经科学
伏隔核
中棘神经元
多巴胺能
谷氨酸的
神经可塑性
神经化学
前额叶皮质
树突棘
心理学
多巴胺
生物
谷氨酸受体
海马结构
纹状体
认知
受体
生物化学
作者
Ben Thompson,Marlene Oscar‐Berman,Gary B. Kaplan
标识
DOI:10.1016/j.neubiorev.2020.10.015
摘要
Opioid Use Disorder (OUD) is a chronic relapsing clinical condition with tremendous morbidity and mortality that frequently persists, despite treatment, due to an individual’s underlying psychological, neurobiological, and genetic vulnerabilities. Evidence suggests that these vulnerabilities may have neurochemical, cellular, and molecular bases. Key neuroplastic events within the mesocorticolimbic system that emerge through chronic exposure to opioids may have a determinative influence on behavioral symptoms associated with OUD. In particular, structural and functional alterations in the dendritic spines of medium spiny neurons (MSNs) within the nucleus accumbens (NAc) and its dopaminergic projections from the ventral tegmental area (VTA) are believed to facilitate these behavioral sequelae. Additionally, glutamatergic neurons from the prefrontal cortex, the basolateral amygdala, the hippocampus, and the thalamus project to these same MSNs, providing an enriched target for synaptic plasticity. Here, we review literature related to neuroadaptations in NAc MSNs from dopaminergic and glutamatergic pathways in OUD. We also describe new findings related to transcriptional, epigenetic, and molecular mechanisms in MSN plasticity in the different stages of OUD.
科研通智能强力驱动
Strongly Powered by AbleSci AI