Low-density lipoprotein receptor-related protein 1 (LRP-1) is associated with high-grade, advanced stage and p53 and p16 alterations in endometrial carcinomas

HistopathologyVolume 59, Issue 3 p. 567-571 Correspondence Low-density lipoprotein receptor-related protein 1 (LRP-1) is associated with high-grade, advanced stage and p53 and p16 alterations in endometrial carcinomas Lluis Catasús, Lluis Catasús Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research (IIB Sant Pau), Barcelona, Spain,Search for more papers by this authorVicenta Llorente-Cortés, Vicenta Llorente-Cortés and Cardiovascular Research Center, CSIC-ICCC, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, SpainSearch for more papers by this authorMiriam Cuatrecasas, Miriam Cuatrecasas Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research (IIB Sant Pau), Barcelona, Spain,Search for more papers by this authorCristina Pons, Cristina Pons Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research (IIB Sant Pau), Barcelona, Spain,Search for more papers by this authorIñigo Espinosa, Iñigo Espinosa Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research (IIB Sant Pau), Barcelona, Spain,Search for more papers by this authorJaime Prat, Jaime Prat Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research (IIB Sant Pau), Barcelona, Spain,Search for more papers by this author Lluis Catasús, Lluis Catasús Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research (IIB Sant Pau), Barcelona, Spain,Search for more papers by this authorVicenta Llorente-Cortés, Vicenta Llorente-Cortés and Cardiovascular Research Center, CSIC-ICCC, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, SpainSearch for more papers by this authorMiriam Cuatrecasas, Miriam Cuatrecasas Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research (IIB Sant Pau), Barcelona, Spain,Search for more papers by this authorCristina Pons, Cristina Pons Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research (IIB Sant Pau), Barcelona, Spain,Search for more papers by this authorIñigo Espinosa, Iñigo Espinosa Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research (IIB Sant Pau), Barcelona, Spain,Search for more papers by this authorJaime Prat, Jaime Prat Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research (IIB Sant Pau), Barcelona, Spain,Search for more papers by this author First published: 28 September 2011 https://doi.org/10.1111/j.1365-2559.2011.03942.xCitations: 15Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Lillis AP, Van Duyn LB, Murphy-Ullrich JE, Strickland DK. LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies. Physiol. Rev. 2008; 88; 887–918. 2 Montel V, Gaultier A, Lester RD, Campana WM, Gonias SL. The LRP1 regulates cancer cell survival and metastasis development. Cancer Res. 2007; 67; 9817–9824. 3 Song H, Li Y, Lee J, Schwartz AL, Bu G. Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9. Cancer Res. 2009; 69; 879–886. 4 Fayard B, Bianchi F, Dey J et al. The serine protease inhibitor protease nexin-1 controls mammary cancer metastasis through LRP-1-mediated MMP-9 expression. Cancer Res. 2009; 69; 5690–5698. 5 Catasus L, Gallardo A, Llorente-Cortes V et al. Low density lipoprotein receptor-related protein 1 (LRP-1) is associated with proliferation and invasiveness in Her-2/neu and triple negative breast carcinomas. Hum. Pathol. 2011: [E-pub ahead of print] DOI: 10.1016/j.humpath.2011.01.011. 6 Dedieu S, Langlois B. LRP-1: a new modulator of cytoskeleton dynamics and adhesive complex turnover in cancer cells. Cell Adh. Migr. 2008; 2; 77–80. 7 Langlois B, Perrot G, Schneider C et al. LRP-1 promotes cancer cell invasion by supporting ERK and inhibiting JNK signaling pathways. PLoS ONE 2010; 5; e11584. 8 Dedieu S, Langlois B, Devy J et al. LRP-1 silencing prevents malignant cell invasion despite increased pericellular proteolytic activities. Mol. Cell. Biol. 2008; 28; 2980–2995. Citing Literature Volume59, Issue3September 2011Pages 567-571 ReferencesRelatedInformation