氯化胆碱
化学
乙二醇
共晶体系
试剂
亲核细胞
催化作用
深共晶溶剂
有机化学
组合化学
合金
作者
Chiara Allegretti,Francesco G. Gatti,Stefano Marzorati,Letizia Anna Maria Rossato,Stefano Serra,Alberto Strini,Paola D’Arrigo
出处
期刊:Catalysts
[MDPI AG]
日期:2021-05-22
卷期号:11 (6): 655-655
被引量:14
标识
DOI:10.3390/catal11060655
摘要
The use of Reactive Deep Eutectic Solvents (RDESs) in the preparation of polar head modified phospholipids (PLs) with phospholipase D (PLD)-catalyzed biotransformations has been investigated. Natural phosphatidylcholine (PC) has been submitted to PLD-catalyzed transphosphatidylations using a new reaction medium composed by a mixture of RDES/buffer. Instead of exploiting deep eutectic solvents conventionally, just as the reaction media, these solvents have been designed here in order to contribute actively to the synthetic processes by participating as reagents. RDESs were prepared using choline chloride or trimethyl glycine as hydrogen-bond acceptors and glycerol or ethylene glycol, as hydrogen-bond donors as well as nucleophiles for choline substitution. Specifically designed RDES/buffer reaction media allowed the obtainment of PLs with optimized yields in the perspective of a sustainable process implementation.
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