奥沙利铂
结直肠癌
医学
免疫系统
CD8型
癌症研究
吲哚胺2,3-双加氧酶
化疗
脾脏
渗透(HVAC)
癌症
免疫学
内科学
生物
色氨酸
生物化学
物理
氨基酸
热力学
作者
Yongxi Zhang,Huijie Jia,Zhiang Liu,Jing Guo,Yang Li,Ruipeng Li,Gaozan Zhu,Jie Li,Minjie Li,Xinyi Li,Shenggen Wang,Chengxue Dang,Tiesuo Zhao
标识
DOI:10.1016/j.intimp.2021.108203
摘要
Colon cancer is one of the most common malignant tumors in the digestive system. Although oxaliplatin, a chemotherapy drug, has been clinically used to treat colon cancer, its therapeutic effect is unsatisfactory. It has been proved that indoleamine dioxygenase 2,3 (IDO) is a tumor immunosuppressive factor for the immune response. Herein, an IDO inhibitor, D-MT (indoximod, 1-Methyl-D-tryptophan), was combined with oxaliplatin to treat colon cancer in mice. T cell infiltration in tumor tissues, the ratios of immune cells in the spleens, and the tumor growth and survival of the mice were detected and recorded. The results showed that the combination of oxaliplatin and D-MT significantly inhibited tumor growth and prolonged the survival of tumor-bearing mice. More importantly, the combination treatment increased the ratios of CD4+ T, CD8+ T and NK cells from the spleen in tumor-bearing mice, and prompted T cell infiltration in tumor tissues. This study provided a new therapeutic strategy for colon cancer treatment in the clinic, especially for patients with oxaliplatin resistance.
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