脾脏
肿瘤坏死因子α
免疫系统
分子生物学
体外
外周血单个核细胞
植物乳杆菌
冰毒-
生物
化学
癌症研究
免疫学
乳酸
生物化学
遗传学
聚合物
细菌
有机化学
丙烯酸酯
单体
作者
Ryoichi Shin,Yukie Itoh,Motoyuki Kataoka,Shiori Iino-Miura,R. Miura,Takeo Mizutani,Tomohiko Fujisawa
标识
DOI:10.1080/09637486.2016.1185771
摘要
Probiotics exert numerous effects on human well-being. Here, heat-killed Lactobacillus plantarum BF-LP284 (H-Lp) was isolated as a potent immuno-modulator among 15 strains of lactobacilli in terms of TNF-α induction ability in peritoneal macrophages. In vitro TNF-α and IFN-γ induction in Peyer's patch (PP) cells was higher when incubated with H-Lp than with live L. plantarum BF-LP284 (L-Lp). Suppression of syngeneic Meth-A tumors in a murine model by oral administration of H-Lp was also greater than that of L-Lp and of controls. H-Lp stimulated IFN-γ production in spleen cells, which displayed inhibited tumor growth in Winn assays when treated with H-Lp. Moreover, H-Lp increased the ratio of CD3+ cells among peripheral blood mononuclear cells in Meth-A tumor-bearing mice, suggesting an H-Lp-mediated anti-tumor mechanism whereby immune cells that are activated by H-Lp in PP and acquire anti-tumor activity in the spleen migrate to tumor sites through lymphocyte homing to inhibit tumor growth.
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