淋巴管新生
角膜
血管生成
医学
角膜新生血管
新生血管
基质金属蛋白酶
成纤维细胞生长因子
血管内皮生长因子
眼科
细胞生物学
血管内皮生长因子受体
癌症研究
生物
癌症
内科学
受体
转移
作者
Nizar Saleh Abdelfattah,Mohamed Amgad,Amira A. Zayed,Heba Hussein,Nawal Abd El‐Baky
标识
DOI:10.18240/ijo.2016.05.24
摘要
The cornea is maintained in an avascular state by maintaining an environment whereby anti-angiogenic factors take the upper hand over factors promoting angiogenesis. Many of the common pathologies affecting the cornea involve the disruption of such equilibrium and the shift towards new vessel formation, leading to corneal opacity and eventually-vision loss. Therefore it is of paramount importance that the molecular underpinnings of corneal neovascularization (CNV) be clearly understood, in order to develop better targeted treatments. This article is a review of the literature on the recent discoveries regarding pro-angiogenic factors of the cornea (such as vascular endothelial growth factors, fibroblast growth factor and matrix metalloproteinases) and anti-angiogenic factors of the cornea (such as endostatins and neostatins). Further, we review the molecular underpinnings of lymphangiogenesis, a process now known to be almost separate from (yet related to) hemangiogenesis.
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