羟醛反应
化学
区域选择性
丙二酸
基础(拓扑)
催化作用
组合化学
有机化学
丙二酸二甲酯
对映选择合成
数学
数学分析
作者
Atul Kumar,Shahnawaz Khan,Qazi Naveed Ahmed
出处
期刊:Organic Letters
[American Chemical Society]
日期:2017-09-06
卷期号:19 (18): 4730-4733
被引量:9
标识
DOI:10.1021/acs.orglett.7b02016
摘要
A practical, atom-economical, base-directed, and highly efficient method for the generation of different selective products through a common aldol intermediate of 2-oxoaldehydes and malonate half esters is successfully developed. The addition of a strong basic environment (potassium tert-butoxide) catalyzed the synthesis of stable decarboxylative aldol products (α-hydroxy ketones), while the Doebner modification procedure resulted in decarboxylative elimination to (E)-α,β-unsaturated esters in good yields. The application of this method in one pot and one pot/two steps with azoles helped to develop regioselective α- and β-azolated products in appreciable yields.
科研通智能强力驱动
Strongly Powered by AbleSci AI