细胞生物学
生物
胚胎干细胞
细胞骨架
管腔(解剖学)
肌动蛋白
过程(计算)
囊泡融合
小泡
脂质双层融合
融合
细胞
解剖
膜
突触小泡
基因
遗传学
语言学
哲学
计算机科学
操作系统
出处
期刊:Results and problems in cell differentiation
日期:2023-11-24
卷期号:: 91-100
标识
DOI:10.1007/978-3-031-37936-9_5
摘要
The Drosophila trachea is an interconnected network of epithelial tubes, which delivers gases throughout the entire organism. It is the premier model to study the development of tubular organs, such as the human lung, kidney, and blood vessels. The Drosophila embryonic trachea derives from a series of segmentally repeated clusters. The tracheal precursor cells in each cluster migrate out in a stereotyped pattern to form primary branches. Thereafter, the neighboring branches need to fuse to form an interconnected tubular network. The connection between neighboring branches is orchestrated by specialized cells, called fusion cells. These cells fuse with their counterparts to form a tube with a contiguous lumen. Branch fusion is a multi-step process that includes cell migration, cell adhesion, cytoskeleton track formation, vesicle trafficking, membrane fusion, and lumen formation. This review summarizes the current knowledge on fusion process in the Drosophila trachea. These mechanisms will greatly contribute to our understanding of branch fusion in mammalian systems.
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