脂肪性肝炎
炎症
免疫系统
肝病
肝硬化
脂肪肝
发病机制
医学
免疫学
肝细胞癌
疾病
脂肪变性
人口
生物信息学
生物
癌症研究
病理
内科学
环境卫生
作者
Shengying Qian,Xiaolin Wang,Yingfen Chen,Qiuhong Zai,Yong He
出处
期刊:Seminars in Liver Disease
[Georg Thieme Verlag KG]
日期:2024-06-05
被引量:1
摘要
Alcohol-related liver disease (ALD) and metabolic dysfunction-associated steatotic liver disease (MASLD), two main types of steatotic liver disease (SLDs), are characterized by a wide spectrum of several different liver disorders, including simple steatosis, steatohepatitis, cirrhosis, and hepatocellular carcinoma. Multiple immune cell-mediated inflammatory responses not only orchestrate the killing and removal of infected/damaged cells but also exacerbate the development of SLDs when excessive or persistent inflammation occurs. In recent years, single-cell and spatial transcriptome analyses have revealed the heterogeneity of liver-infiltrated immune cells in ALD and MASLD, revealing a new immunopathological picture of SLDs. In this review, we will emphasize the roles of several key immune cells in the pathogenesis of ALD and MASLD and discuss inflammation-based approaches for effective SLD intervention. In conclusion, the study of immunological mechanisms, especially highly specific immune cell population functions, may provide novel therapeutic opportunities for this life-threatening disease.
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