Highly antibacterial behavior of casted films for wound dressings based on cellulose acetate containing dual compositions of ZnO and silver vanadate

This study focuses on enhancing the biological activity of cellulose acetate (CA) scaffolds through modifications using zinc oxide (ZnO), silver vanadate (Ag3VO4), and graphene oxide. The aim is to improve the contact angle, cell viability, and antibacterial characterization of the CA scaffold. Notably, the addition of ZnO and Ag3VO4 to the CA film significantly reduces the contact angle from 40.9° ± 3.145–27.11° ± 0.97, indicating improved surface properties. Furthermore, the incorporation of these additives leads to a notable increase in cell viability, reaching approximately 120 % viable cells at a concentration of about 2.44 μg/ml. The modified CA scaffold, particularly with S5 composition, exhibits strong antibacterial activity against E. coli and S. aureus, with measured values of approximately 10.7 % ± 0.4 and 10.75 % ± 0.5 against the control, respectively. Overall, this study highlights the significance of modifying CA scaffolds with ZnO, Ag3VO4, and graphene oxide, presenting advancements in wound healing materials with improved surface properties, enhanced cell viability, and effective antibacterial activity. These findings contribute to the field's knowledge and hold promise for future developments in wound healing applications.