伤口愈合
医学
炎症
MAPK/ERK通路
血管生成
皮肤修复
PI3K/AKT/mTOR通路
再生(生物学)
药理学
信号转导
外科
癌症研究
免疫学
细胞生物学
生物
作者
Shahnai Basharat,Sarosh Malik,Hodaa Usama Abdus Samad,Mian Anjum Murtaza
出处
期刊:Wounds-a Compendium of Clinical Research and Practice
[HMP Communications, LLC]
日期:2024-01-01
卷期号:36 (08): 274-280
摘要
Fish skin has emerged as a potential candidate for improving wound healing due to its notable results in human trials, in which it has been directly applied as a dressing on wounds. The current review explores the mechanisms by which fish skin can boost the wound healing process. The natural wound healing process involves inflammation at the wound site to initiate tissue repair. The body balances this inflammation through interleukin signaling, and imbalances can cause chronic wounds or scarring. The wound site also secretes epidermal growth factor, which activates the Ras/Raf/MEK/ERK and PI3K/Akt pathways. These pathways promote angiogenesis (ie, replacing injured blood vessels) and epithelialization (ie, replacing injured skin). Delays in these pathways increase the healing time. The rich contents of omega-3, collagen, and selenium in fish skin boost wound healing by inhibiting compounds that can cause over-inflammation during interleukin signaling. They also upregulate the Ras/Raf/MEK/ERK and PI3K pathways by altering lipid composition (via omega-3), binding with collagen receptors (via collagen), and modulating selenoproteins (via selenium). The mechanisms discussed in this review support the finding that fish skin is a promising candidate with a strong potential to naturally boost the wound healing process in clinical settings. Continued investigation into the application of fish skin as a practical and commercial wound healing agent is warranted. Future study of additional wound healing properties of fish skin, such as microbial protection of open wounds, is recommended.
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