Skeletal muscle function is altered in male mice on low-dose androgen receptor antagonist or estrogen receptor agonist

Changes in skeletal muscle function in males may be due to altered sex hormone status from obesity, prostate cancer, or in transitioning males-to-females. Using individual skeletal muscle fibers from the slow-contracting soleus and fast-contracting extensor digitorum longus muscles from adult male mice, we examined the effect of acute (2 week) exposures to flutamide, an androgen receptor (AR) antagonist, or 17α-ethinyl estradiol (EE2), an estrogen receptor (ER) agonist against an age-matched control group.