鼻腔给药
药物输送
药品
药理学
透皮
生物利用度
医学
血脑屏障
靶向给药
中枢神经系统
纳米技术
材料科学
内科学
作者
Esraa Taha,Amro Shetta,Samia A. Nour,Marianne J. Naguib,Wael Mamdouh
标识
DOI:10.1021/acs.molpharmaceut.3c00588
摘要
The intranasal route has proven to be a reliable and promising route for delivering therapeutics to the central nervous system (CNS), averting the blood–brain barrier (BBB) and avoiding extensive first-pass metabolism of some drugs, with minimal systemic exposure. This is considered to be the main problem associated with other routes of drug delivery such as oral, parenteral, and transdermal, among other administration methods. The intranasal route maximizes drug bioavailability, particularly those susceptible to enzymatic degradation such as peptides and proteins. This review will stipulate an overview of the intranasal route as a channel for drug delivery, including its benefits and drawbacks, as well as different mechanisms of CNS drug targeting using nanoparticulate drug delivery systems devices; it also focuses on pharmaceutical dosage forms such as drops, sprays, or gels via the nasal route comprising different polymers, absorption promoters, CNS ligands, and permeation enhancers.
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