Increased cardiovascular and atherosclerosis markers in blood of older patients with atopic dermatitis

医学 特应性皮炎 促炎细胞因子 免疫学 内科学 炎症 全身炎症 趋化因子 胃肠病学
作者
Helen He,Randall Li,Seulah Choi,Lisa Zhou,Ana B. Pavel,Yeriel Estrada,James G. Krueger,Emma Guttman‐Yassky
出处
期刊:Annals of Allergy Asthma & Immunology [Elsevier]
卷期号:124 (1): 70-78 被引量:72
标识
DOI:10.1016/j.anai.2019.10.013
摘要

Background Atopic dermatitis (AD) is associated with increased systemic inflammation and cardiovascular risk. Although previous studies have found increased inflammatory proteins in the blood of patients with AD, detailed comparison among patients with AD of different ages is unavailable. Objective To characterize the blood proteomic signature of patients with AD as a function of age. Methods We used the OLINK high-throughput proteomic assay to measure serum inflammatory and cardiovascular risk proteins in 71 patients with moderate to severe AD from 3 age groups (18-40 years old [n = 26], 41-60 years old [n = 24], and >60 years old [n = 21]) compared with 37 age-matched controls. Total and allergen-specific serum IgEs were also measured. Results When we compared patients with AD from 3 different age groups with their respective controls, we identified a total of 172 differentially expressed proteins. TH2 chemokines (CCL13, CCL17) were consistently elevated in patients with AD across all ages (P < .05), whereas TH1 (CXCL10) and TH17 (KYNU, CCL20) markers incrementally increased with age in both patients with AD and healthy subjects. Elderly patients with AD (>60 years old) exhibited striking upregulation of key proinflammatory proteins, including markers of atherosclerosis (CCL4, CCL7, SORT1), cardiovascular risk (GDF15, MPO, ST2), cell adhesion (CDH3), and apoptosis (FAS; all P < .05) compared with younger patients with AD and age-matched controls. We also found that total and allergen-specific serum IgEs decreased significantly with age in patients with AD (P < .05). Conclusion Elderly patients with AD had increased levels of systemic inflammatory markers, including those associated with cardiovascular and atherosclerosis risk, which may explain their increased incidence of cardiovascular disease. This finding suggests that older patients with AD may benefit from cardiovascular disease screening and prevention.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
共享精神应助风评采纳,获得10
1秒前
文静的峻熙完成签到,获得积分10
1秒前
桐桐应助IAMXC采纳,获得10
1秒前
2秒前
向上先生发布了新的文献求助10
2秒前
充电宝应助科研通管家采纳,获得30
2秒前
李健应助科研通管家采纳,获得10
2秒前
3秒前
赘婿应助科研通管家采纳,获得10
3秒前
元谷雪应助科研通管家采纳,获得10
3秒前
李爱国应助科研通管家采纳,获得30
3秒前
木子发布了新的文献求助10
3秒前
3秒前
夏遥发布了新的文献求助10
3秒前
NaNa发布了新的文献求助10
4秒前
整齐的远侵完成签到,获得积分10
5秒前
今后应助呦吼。。。采纳,获得20
8秒前
研友_ngK9rn完成签到,获得积分10
10秒前
杉进完成签到 ,获得积分10
11秒前
祺志鲜明完成签到,获得积分10
12秒前
太渊完成签到 ,获得积分20
14秒前
小乖完成签到 ,获得积分10
14秒前
Akim应助天易采纳,获得10
14秒前
毛豆爸爸应助Khan采纳,获得20
14秒前
kento应助Die采纳,获得100
15秒前
16秒前
破晓完成签到,获得积分10
16秒前
太叔千愁完成签到,获得积分10
16秒前
dl完成签到,获得积分10
17秒前
jie367完成签到,获得积分10
19秒前
科目三应助贪玩的书包采纳,获得10
20秒前
20秒前
NaNa完成签到,获得积分10
20秒前
XTM发布了新的文献求助10
21秒前
大头不愁完成签到 ,获得积分10
22秒前
freya完成签到,获得积分10
24秒前
医研丁真完成签到 ,获得积分10
25秒前
桐桐应助刘振坤采纳,获得30
26秒前
Die完成签到,获得积分10
28秒前
Leon_nomoreLess完成签到 ,获得积分10
29秒前
高分求助中
Sustainability in Tides Chemistry 2800
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
Foreign Policy of the French Second Empire: A Bibliography 500
Chen Hansheng: China’s Last Romantic Revolutionary 500
XAFS for Everyone 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3143779
求助须知:如何正确求助?哪些是违规求助? 2795335
关于积分的说明 7814327
捐赠科研通 2451315
什么是DOI,文献DOI怎么找? 1304413
科研通“疑难数据库(出版商)”最低求助积分说明 627221
版权声明 601419