纳米器件
癌症免疫疗法
免疫系统
抗原
癌症疫苗
dna疫苗
免疫疗法
癌症
DNA
癌细胞
材料科学
癌症研究
纳米技术
免疫学
生物
遗传学
免疫
生物化学
作者
Shaoli Liu,Qiao Jiang,Xiao Zhao,Ruifang Zhao,Yuanning Wang,Yiming Wang,Jianbing Liu,Yingxu Shang,Shuai Zhao,Tiantian Wu,Yinlong Zhang,Guangjun Nie,Baoquan Ding
出处
期刊:Nature Materials
[Springer Nature]
日期:2020-09-07
卷期号:20 (3): 421-430
被引量:397
标识
DOI:10.1038/s41563-020-0793-6
摘要
A major challenge in cancer vaccine therapy is the efficient delivery of antigens and adjuvants to stimulate a controlled yet robust tumour-specific T-cell response. Here, we describe a structurally well defined DNA nanodevice vaccine generated by precisely assembling two types of molecular adjuvants and an antigen peptide within the inner cavity of a tubular DNA nanostructure that can be activated in the subcellular environment to trigger T-cell activation and cancer cytotoxicity. The integration of low pH-responsive DNA ‘locking strands’ outside the nanostructures enables the opening of the vaccine in lysosomes in antigen-presenting cells, exposing adjuvants and antigens to activate a strong immune response. The DNA nanodevice vaccine elicited a potent antigen-specific T-cell response, with subsequent tumour regression in mouse cancer models. Nanodevice vaccination generated long-term T-cell responses that potently protected the mice against tumour rechallenge. A DNA nanodevice vaccine has been developed and utilized to stimulate a tumour-specific cytotoxic T lymphocyte response in vivo, leading to the inhibition of tumour growth as well as prevention of metastasis.
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